About

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. New hire with clinical research focus and skills in Vascular Biology, Human Genetics, and Fibromuscular Dysplasia (FMD) Job Summary We are seeking a highly motivated Postdoctoral Fellow to join an international, multidisciplinary research program focused on defining the human genetic, molecular, and cellular mechanisms underlying fibromuscular dysplasia (FMD) and related arteriopathies, including spontaneous coronary artery dissection (SCAD) and cervical artery dissection (CeAD). The fellow will work within the ALIGN-FMD Network, a global collaboration that integrates human genetics, vascular cell biology, multi-omics, and in vivo modeling to advance mechanistic understanding and identify therapeutic targets for FMD. Qualifications Key Responsibilities Analyze and interpret human genetic data related to FMD, SCAD, and CeAD, including rare variant, common variant, and gene-burden analyses Integrate human genetic findings with downstream cellular and in vivo functional studies Design and execute experimental studies investigating vascular smooth muscle cell (VSMC) and extracellular matrix (ECM) dysfunction driven by genetically prioritized targets Perform and analyze in vitro and ex vivo cellular models, including primary human VSMCs, iPSC-derived smooth muscle cells, and engineered vascular tissues Apply genome engineering approaches (e.g., CRISPR/Cas9-based perturbations) to model human genetic variants and regulatory mechanisms Contribute to murine models of arterial remodeling, vascular integrity, and sex-specific disease mechanisms Prepare manuscripts, figures, and presentations for peer-reviewed publication and scientific meetings Required Skills and Experience PhD (or MD/PhD) in human genetics, cardiovascular biology, vascular biology, genomics, molecular biology, or a related field Demonstrated experience in human genetics, including analysis or interpretation of genome-wide association studies (GWAS), whole-exome sequencing (WES), whole-genome sequencing (WGS), or rare-variant analyses Strong background in cell and molecular biology, ideally with experience working with vascular smooth muscle cells or related cell types Hands-on experience with one or more of the following: Genomic variant annotation and prioritization CRISPR/Cas9 or other genome-editing approaches iPSC culture and differentiation Murine models of cardiovascular or connective tissue disease Ability to work with complex datasets and translate human genetic findings into testable biological hypotheses Strong written and verbal communication skills, with a record of or clear potential for peer-reviewed publication Qualified candidates, please email a CV and cover letter to Dr. Mark Lindsay: Lindsay.Mark@mgh.harvard.edu Preferred Qualifications Experience integrating human genetic data with functional genomics or multi-omics datasets Familiarity with statistical genetics, bioinformatics pipelines, or collaborative data analysis environments Experience studying extracellular matrix biology, collagen remodeling, or arterial biomechanics Interest in sex-specific genetic effects and vascular disease mechanisms Additional Job Details (if applicable) Physical Requirements Standing N/A = (0%) Walking N/A = (0%) Sitting N/A = (0%) Lifting N/A = (0%) Carrying N/A = (0%) Pushing N/A = (0%) Pulling N/A = (0%) Climbing N/A = (0%) Balancing N/A = (0%) Stooping N/A = (0%) Kneeling N/A = (0%) Crouching N/A = (0%) Crawling N/A = (0%) Reaching N/A = (0%) Gross Manipulation (Handling) N/A = (0%) Fine Manipulation (Fingering) N/A = (0%) Feeling N/A = (0%) Foot Use N/A = (0%) Vision - Far N/A = (0%) Vision - Near N/A = (0%) Talking N/A = (0%) Hearing N/A = (0%) EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. Remote Type Hybrid Work Location 185 Cambridge Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: 1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.